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Invitrogen™ ARHGEF1 Polyclonal Antibody
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Product Code. 16549121
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Quantity:
100 μL
Unit Size:
100µL
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16549121 100 μL 100µL
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Product Code. 16549121 Supplier Invitrogen™ Supplier No. PA596281

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PLLSSSENGN GGRETSPADA RTERILSDLL PFCRPGPEGQ LAATALRKVL SLKQLLFPAE EDNGAGPPRD GDGVPGGGPL SPARTQEIQE NLLSLEETMK QLEELEEEFC RLRPLLSQLG GNSVPQPGCT; Positive Samples: HeLa, Jurkat, LO2; Cellular Location: Cytoplasm, Membrane.

The Ras superfamily of GTPases, which can be subdivided into the Ras, Rho/Rac, Sar, Rab, ARF and Ran subfamilies, controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. The Ras superfamily of GTPases function as regulated switches that toggle between a biologically active GTP-bound and an inactive GDP-bound form. This activation is catalyzed by guanine nucleotide exchange factors (GEFs). The Dbl-related proteins are a large family of structurally related molecules that have a common ability to catalyze GEF activity for specific members of the Ras family. Dbl-related proteins include FGD1, Lsc, RhoGEF p115, Lfc, Lbc and Brx. Lsc, Lbc and Lfc share sequence homology and show exchange activity toward Rho family GTPases. RhoGEF p115 catalyzes GEF activity for Rho but not Rac, Cdc42 or Ras GTPases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.45 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Arhgef1
Gene Accession No. Q92888, Q9Z1I6
Gene Alias 115 kDa guanine nucleotide exchange factor; 115-kD protein; ARHGEF1; GEF1; LBCL2; Lbc's second cousin; Lsc; Lsc homolog; lymphoid blast crisis like 2; lymphoid blast crisis-like 2; p115RhoGEF; p115-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 1; Rho guanine nucleotide exchange factor 1; Sub1.5
Gene Symbols Arhgef1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_0046972).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60323, 9138
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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