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Invitrogen™ ARS2 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531593

Product Code. 13476117

  • € 520.00 / 100µL

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Description

Description

Recommended positive controls: 293T, A431, Jurkat, Raji, HeLa, HepG2. Predicted reactivity: Mouse (97%), Zebrafish (80%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. [UniProt].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ARS2
Polyclonal
Unconjugated
SRRT
2810019G02Rik; Ars2; arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; arsenite resistance protein 2; arsenite-resistance protein 2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D; ch211-283g2.4; CHUNP6881; LOC686980; serrate; Serrate RNA effector molecule homolog; serrate RNA effector molecule homolog (Arabidopsis); serrate, RNA effector molecule; similar to arsenate resistance protein 2; srrt; zgc:92060
Rabbit
Antigen affinity chromatography
RUO
51593
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
0.76 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Q9BXP5
SRRT
Recombinant protein encompassing a sequence within the N-terminus region of human ARS2. The exact sequence is proprietary.
100 μL
Primary
Human
Antibody
IgG
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