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Invitrogen™ ASAH1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA534831
This item is not returnable.
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Description
Recommended positive controls: NT2D1, mouse heart, mouse muscle. Predicted reactivity: Mouse (81%), Rat (84%), Chimpanzee (100%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. The processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene have been linked to the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. The related pathways include Innate Immune System and Sphingolipid metabolism. Diseases associated with ASAH1 include Farber Lipogranulomatosis and Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy.
Specifications
| ASAH1 | |
| Polyclonal | |
| Unconjugated | |
| ASAH1 | |
| 2310081N20Rik; AC; ACDase; acid CDase; acid ceramidase; Acid ceramidase subunit alpha; Acid ceramidase subunit beta; Acylsphingosine deacylase; ASAH; Asah1; HSD33; HSD-33; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase; N-acylsphingosine amidohydrolase (acid ceramidase) 1; N-acylsphingosine amidohydrolase 1; PHP; PHP32; putative 32 kDa heart protein; SMAPME | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 11886, 427 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1.99 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| Q13510, Q9WV54 | |
| ASAH1 | |
| Recombinant protein encompassing a sequence within the center region of human ASAH1. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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