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ATG16L1 Mouse anti-Human, Clone: OTI2A10, lyophilized, TrueMAB™

Product Code. 17670612
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Quantity:
100 μg
Unit Size:
100µg
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17670612 100 μg 100µg
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Product Code. 17670612 Supplier Origene Technologies Supplier No. CF809571

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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.

Specifications

Antigen ATG16L1
Applications Western Blot
Classification Monoclonal
Clone OTI2A10
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene ATG16L1
Gene Accession No. Q676U5
Gene Alias APG16L, ATG16A, ATG16L, IBD10, WDR30
Gene Symbols ATG16L1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-277 of human ATG16L produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55054
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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