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Invitrogen™ ATG4B Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA591844
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Description
Positive Samples: HepG2, BT-474, SKOV3, HeLa, Jurkat; Cellular Location: Cytoplasm Immunogen sequence: MDAATLTYDT LRFAEFEDFP ETSEPVWILG RKYSIFTEKD EILSDVASRL WFTYRKNFPA IGGTGPTSDT GWGCMLRCGQ MIFAQALVCR HLGRDWRWTQ RKRQPDSYFS VLNAFIDRKD SYYSIHQIAQ MGVGEGKSIG QWYGPNTVAQ VLKKLAVFDT WSSLAVHIAM DNTVVMEEIR RLCRTSVPCA GATAFPADSD RHCNGFPAGA EVTNRPSPWR PLVLLIPLRL GLTDINEAYV ETLKHCFMMP QSLGVIGGKP NSAHYFIGYV GEELIYLDPH TTQPAVEPTD GCFIPDESFH CQHPPCRMSI AELDPSIAVG FFCKTEDDFN DWCQQVKKLS LLGGALPMFE LVELQPSHLA CPDVLNLSLD SSDVERLERF FDSEDEDFEI LSL.
Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4bis a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
Specifications
| ATG4B | |
| Polyclonal | |
| Unconjugated | |
| Atg4b | |
| 2510009N07Rik; APG4 (ATG4) autophagy-related homolog B; APG4 autophagy 4 homolog B; APG4B; ATG4 autophagy related 4 homolog B; Atg4b; atg4b protein; Atg4bl; AUT2B; Aut2B1; Aut2b2; AUTL1; AUT-like 1 cysteine; AUT-like 1 cysteine endopeptidase; AUT-like 1, cysteine endopeptidase; autophagin 1; autophagin-1; Autophagin-2B; autophagy related 4 homolog B; autophagy related 4B cysteine peptidase; autophagy related 4B, cysteine peptidase; autophagy-related 4B; autophagy-related cysteine endopeptidase 1; Autophagy-related cysteine endopeptidase 2B; autophagy-related protein 4 homolog B; AW048066; bAut2B; Cysteine protease ATG4B; cysteine protease involved in autophagy APG4-B; hAPG4B; KIAA0943 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 23192, 66615 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot | |
| 2.39 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q8BGE6, Q9Y4P1 | |
| Atg4b | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human ATG4B (NP_0374573). | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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