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  6. Invitrogen™ Aurora B Monoclonal Antibody (6G2)

Invitrogen™ Aurora B Monoclonal Antibody (6G2)

Product Code. p-7246556
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500 μL
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Product Code. Quantity unitSize
17856847 500 μL 500µL
17876607 100 μL 100µL
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Product Code. 17856847 Supplier Invitrogen™ Supplier No. MA547363

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Description

Mouse Monoclonal Antibody

Aurora B Monoclonal Antibody for Western Blot, IHC, ICC/IF

The Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aurora B
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 6G2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 5mM sodium azide
Gene AURKB
Gene Accession No. Q96GD4
Gene Alias Aik2; AIM1; AIM-1; AIRK2; AL022959; ARK2; ARK-2; AurB; AURKB; aurkb-sv1; aurkb-sv2; aurora 1; aurora- and IPL1-like midbody-associated protein 1; aurora B; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK1; STK-1; Stk12; STK12; AIK2; AIM1; ARK2; IPL1; AIM-1; STK5
Gene Symbols AURKB
Host Species Mouse
Immunogen Full length human recombinant aurora B protein expressed in and purified from E. Coli.
Purification Method Protein A/G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100073050, 479492, 9212
Target Species Human, Canine, Horse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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