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Invitrogen™ B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (RM8), Biotin
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Product Code. 17886731
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Quantity:
50 μg
Unit Size:
50µg
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17886731 50 μg 50µg
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Product Code. 17886731 Supplier Invitrogen™ Supplier No. MA544555

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Description

Rabbit Recombinant Monoclonal Antibody

This antibody reacts to the Histone H3.3 G34R mutant. No cross reactivity with wild type Histone H3.3.

This gene, B-RAF/BRAF, encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.
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Specifications

Antigen B-Raf (V600E)
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone RM8
Concentration 1 mg/mL
Conjugate Biotin
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene BRAF
Gene Accession No. P15056
Gene Symbols BRAF
Host Species Rabbit
Immunogen A peptide corresponding to BRAF V600E mutant. The immunogen range is a synthetic peptide within amino acids 550-650 of Akt with V600E mutant.
Purification Method Protein A
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 673
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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