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beta 2-Microglobulin Antibody (B2M/961), Alexa Fluor™ 750, Novus Biologicals™
Mouse Monoclonal Antibody
Brand: Novus Biologicals NBP2-47704AF750
This item is not returnable.
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Description
beta 2-Microglobulin Monoclonal specifically detects beta 2-Microglobulin in Human, Primate samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Flow (Cell Surface), Immunofluorescence.
Specifications
| beta 2-Microglobulin | |
| Monoclonal | |
| Alexa Fluor 750 | |
| 50 mM sodium borate with 0.05% sodium azide | |
| B2M | |
| Full length recombinant human beta 2-Microglobulin protein (Uniprot: P61769 ) | |
| 0.1 mL | |
| Primary | |
| Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. | |
| Store at 4°C in the dark. |
| Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence | |
| B2M/961 | |
| Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Flow (Cell Surface), Immunofluorescence | |
| beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin | |
| Mouse | |
| Protein A or G purified | |
| Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology | |
| 567.0 | |
| Human, Primate | |
| IgG2b κ |
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