missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ BID Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA126485
This item is not returnable.
View return policy
Description
PA1-26485 detects Bid from mouse samples.
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
Specifications
| BID | |
| Polyclonal | |
| Unconjugated | |
| BID | |
| 2700049M22Rik; AI875481; apoptic d; apoptic death agonist; apoptotic death agonist BID; AU022477; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; Bid; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; desmocollin type 4; FP497; HGNC:1050; Human BID coding sequence; MGC15319; MGC42355; OTTHUMP00000196197; p11 BID; p13 BID; p15 BID; p22 BID | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 12122 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 0.5 mg/mL | |
| PBS with 0.5% BSA, 30% glycerol and 0.01% thimerosal; pH 7.2 | |
| P70444 | |
| BID | |
| Synthetic peptide surrounding amino acid 45 of mouse Bid. | |
| 50 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction