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Invitrogen™ BIN1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA582188
This item is not returnable.
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Description
Immunogen sequence: VTAGKIASNV QKKLTRAQEK VLQKLGKADE TKDEQFEQCV QNFNKQLTEG TRLQKDLRTY LASVKAMHEA SKKLNECLQE VYEPDWPGRD EANKIAENND LLWMDYHQKL VDQALLTMDT YLGQFPDIKS RIAKRGRKLV DYDSARHH Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Specifications
| BIN1 | |
| Polyclonal | |
| Unconjugated | |
| BIN1 | |
| ALP-1; AMPH 2; Amph2; amphiphysin 2; amphiphysin II; amphiphysin IIamph2; amphiphysin-like; amphiphysin-like protein; AMPHL; Bin1; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; BRAMP-2; bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; myc box dependent interacting protein 1; myc box-dependent-interacting protein 1; SH3 domain-containing protein 9; SH3P9; similar to bridging integrator 1 isoform 9 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 274 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| O00499 | |
| BIN1 | |
| Recombinant protein corresponding to Human BIN1. Recombinant protein control fragment (Product #RP-89206). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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