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  8. BMS-599626 Hydrochloride, MedChemExpress

BMS-599626 Hydrochloride, MedChemExpress

Product Code. 16481157
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Product Code. 16481157 Supplier Medchem Express Supplier No. HY12010

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Description

MedChemExpress BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ∼8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.

BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ∼8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.

Specifications

Chemical Name or Material BMS-599626 Hydrochloride
CAS 873837-23-1
Color White
Purity Grade Notes Research
Molecular Formula C27H28ClFN8O3
Quantity 50 mg
Synonym AC480 Hydrochloride
Solubility Information DMSO : 100 mg/mL (176.36 mM; Need ultrasonic)
SMILES O=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl
Molecular Weight (g/mol) 567.01
Formula Weight 567.01
Percent Purity 99.87%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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