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  5. STEMCELL Technologies Brefeldin A

STEMCELL Technologies Brefeldin A

Product Code. 17130162
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Quantity:
10 mg
25 mg
Unit Size:
10mg
25mg
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Product Code. 17130162

Brand: STEMCELL Technologies 73014

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This item is not returnable. View return policy

Description

Protein trafficking inhibitor; Inhibits Sec7-containing guanine-exchange factor (GEF)

  • Brefeldin A is a fungal lactone antibiotic, produced by many species, including Eupenicillium brefeldianum (Klausner et al.) It reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by indirect inhibition of ADP-ribosylation factor (ARF; Klausner et al.; Helms & Rothman; Robinson et al.; Morinaga et al.; Moss & Vaughan; Nebenführ et al.; Ktistakis et al.) Brefeldin A binds to Sec7-containing guanine-exchange factor (GEF) at the ARF-GDP-Sec7 interface, preventing the conformational change required to release GDP and activate ARF (Mossessova et al.)

Specifications

CAS 20350-15-6
Synonym Ascotoxin; BFA; Cyanein; Decumbin; Nectrolide; NSC 56310; NSC 89671; NSC 107456; NSC 244390; Synergisidin
Quantity 25 mg
Molecular Formula C16H24O4
Purity ≥98%
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