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  5. Tocris Bioscience™ Brequinar sodium

Tocris Bioscience™ Brequinar sodium
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Product Code. 18766016
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18766016

Brand: Tocris Bioscience™ 6196/50

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Description

Potent and selective DHODH inhibitor.

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ∽20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ∽ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium
CAS 96201-88-6
Assay Percent Range >99%
Quantity 50 mg
Target DHODH Inhibitors
Molecular Formula C23H14F2NO2Na
Formula Weight Observed MW: 397.35
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