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Invitrogen™ C14orf126 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA524053

Product Code. 13268128

  • € 520.00 / 400µL

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Description

Description

C14orf126 Polyclonal Antibody for Western Blot

Deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation. [UniProt].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

C14orf126
Polyclonal
Unconjugated
DTD2
4930578F06Rik; 6530401N04Rik; Animalia-specific tRNA deacylase; ATD; B830049N13Rik; C14orf126; D-aminoacyl-tRNA deacylase 2; DTD2; D-tyrosyl-tRNA deacylase 2; D-tyrosyl-tRNA deacylase 2 (putative); D-tyrosyl-tRNA(Tyr) deacylase 2; L-alanyl-tRNA deacylase; probable D-tyrosyl-tRNA(Tyr) deacylase 2
Rabbit
Antigen Affinity Chromatography, Protein A
RUO
112487, 328092
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.4
Q8BHA3, Q96FN9
DTD2
KLH conjugated synthetic peptide between 136-164 amino acids from the C-terminal region of human C14orf126.
400 μL
Primary
Human, Mouse
Antibody
IgG
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