Invitrogen™ C14orf21 Polyclonal Antibody

Description

Recommended positive controls: A549. Predicted reactivity: Mouse (80%), Rat (83%), Rhesus Monkey (98%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The C14orf21 gene, also known as SLIRP (SRA stem-loop interacting RNA binding protein), is located on chromosome 14 and encodes a mitochondrial protein involved in RNA processing. SLIRP is crucial for the stabilization and regulation of mitochondrial-encoded RNAs, which play a vital role in mitochondrial gene expression and overall mitochondrial function. The SLIRP protein interacts with RNA stem-loop structures, particularly those involved in the steroid receptor RNA activator (SRA), thereby regulating gene expression by modulating the activity of nuclear receptors. Defects in SLIRP can lead to impaired mitochondrial function, resulting in various clinical manifestations, including mitochondrial myopathy and other disorders related to mitochondrial dysfunction.