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C4B Monoclonal Antibody (OTI1B2), TrueMAB™, OriGene

Product Code. 17597624
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100 μL
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30µL
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17597624 100 μL 100µL
17517634 30 μL 30µL
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Product Code. 17597624 Supplier Origene Technologies Supplier No. TA813010

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Description

Mouse Monoclonal Antibody

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Specifications

Antigen C4B
Applications Western Blot
Classification Monoclonal
Clone OTI1B2
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene C4B
Gene Accession No. P0C0L5
Gene Alias C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
Gene Symbols C4B
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1100-1350 of human C4B produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 721
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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