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Invitrogen™ CAB39 Polyclonal Antibody
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Product Code. 16629424
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Quantity:
100 μL
Unit Size:
100µL
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16629424 100 μL 100µL
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Product Code. 16629424 Supplier Invitrogen™ Supplier No. PA5102968

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CAB39.

Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CAB39
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CAB39
Gene Accession No. Q06138, Q9Y376
Gene Alias AA408805; AA960512; C78372; Cab39; calcium binding protein 39; calcium binding protein, 39 kDa; calcium-binding protein 39; CGI-66; MO25; MO25alpha; Protein Mo25
Gene Symbols CAB39
Host Species Rabbit
Immunogen A synthesized peptide derived from human CAB39(Accession Q9Y376), corresponding to amino acid residues Q289-Q339.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12283, 51719
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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