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Invitrogen™ Calreticulin 3 Polyclonal Antibody
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Product Code. 13483437
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Quantity:
100 μL
Unit Size:
100µL
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13483437 100 μL 100µL
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Product Code. 13483437 Supplier Invitrogen™ Supplier No. PA529451

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (81%), Rat (83%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Calreticulin 3 (CALR3) is a gene located on chromosome 19p13.11, encoding a member of the calreticulin family of calcium-binding chaperones. Unlike the more ubiquitously expressed calreticulin (CALR), CALR3 is specifically expressed in the testes and plays a crucial role in spermatogenesis. CALR3 is involved in the quality control of proteins within the endoplasmic reticulum (ER) and assists in the folding and assembly of newly synthesized glycoproteins. This protein's function is essential for the maturation of sperm cells and male fertility, as it helps ensure the proper formation and function of sperm-specific proteins. Mutations in CALR3 have been associated with familial hypertrophic cardiomyopathy, reflecting its potential involvement in cardiac muscle function through mechanisms that remain to be fully elucidated. Research continues to explore CALR3's specific roles in reproductive biology and its implications in hereditary conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calreticulin 3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Calr3
Gene Accession No. Q96L12, Q9D9Q6
Gene Alias 1700031L01Rik; 6330586I20Rik; CALR3; calreticulin 3; calreticulin-2; Calreticulin-3; calspeculin; calsperin; cancer/testis antigen 93; CMH19; CRT2; cspn; CT93; EGK_10275; testis secretory sperm-binding protein Li 226n
Gene Symbols Calr3
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Calreticulin 3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 125972, 73316
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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