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Invitrogen™ CCDC8 Polyclonal Antibody
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100 μg
Unit Size:
100µg
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17101294 100 μg 100µg
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Product Code. 17101294 Supplier Invitrogen™ Supplier No. PA5113429

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Description

Rabbit Polyclonal Antibody

CCDC8 Polyclonal Antibody for Western Blot, ICC/IF, ELISA

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCDC8
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene CCDC8
Gene Accession No. D3YZV8, Q9H0W5
Gene Alias 3M3; CCDC8; coiled-coil domain containing 8; coiled-coil domain containing protein 8; coiled-coil domain-containing protein 8; Coiled-coil domain-containing protein 8 homolog; ENSMUSG00000041117; p90; PPP1R20; probable Coiled-coil domain-containing protein 8; protein phosphatase 1, regulatory subunit 20
Gene Symbols CCDC8
Host Species Rabbit
Immunogen Recombinant Human Coiled-coil domain-containing protein 8 protein (214-513AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 434130, 83987
Target Species Human, Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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