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Invitrogen™ CCR2 Polyclonal Antibody, DyLight™ 550
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Product Code. 13218198
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Quantity:
100 μL
Unit Size:
100µL
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13218198 100 μL 100µL
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Product Code. 13218198 Supplier Invitrogen™ Supplier No. PA523048

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Description

Rabbit Polyclonal Antibody

CCR2 Polyclonal Antibody for IHC (F), ICC/IF, Flow

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCR2
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunocytochemistry
Classification Polyclonal
Concentration 0.73 mg/mL
Conjugate DyLight 550
Formulation 50mM sodium borate with 0.05% sodium azide
Gene Ccr2
Gene Accession No. P41597, P51683
Gene Alias C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; C-C motif chemokine receptor 2; Cc-ckr2; CC-CKR-2; Ccr2; CCR-2; Ccr2a; CCR2B; CD192; CD192 antigen; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2; chemokine receptor CCR2; Ckr2; Ckr2a; Ckr2b; CMKBR2; hCG_14621; JE/FIC receptor; Mcp1 receptor; MCP-1 receptor; Mcp1r; MCP-1-R; MIP-1 alphaR; mJe-r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Gene Symbols Ccr2
Host Species Rabbit
Immunogen Synthetic peptide made to an N-terminal portion of the mouse CCR2 protein (within residues 20-100).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12772, 729230
Target Species Human, Mouse
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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