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CD106 (VCAM-1) Monoclonal Antibody (429), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

€ 67.00 - € 256.00

Specifications

Antigen CD106 (VCAM-1)
Clone 429
Concentration 0.5 mg/mL
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15277157
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Affymetrix eBioscience
14-1061-82
100 μg
€ 118.00
100µg
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Estimated Shipment: 07-05-2024
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15287157
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Affymetrix eBioscience
14-1061-85
500 μg
€ 256.00
500µg
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In Stock
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15267157
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Affymetrix eBioscience
14-1061-81
50 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response. Applications Reported: This 429 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunohistochemical staining of frozen tissue sections (IHC-F). It has also been reported in blocking of CD106 in functional studies. (Please use Functional Grade purified 429, cat. 16-1061, in functional assays.). Applications Tested: The 429 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

VCAM-1 is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases.
Specifications

Specifications

CD106 (VCAM-1)
0.5 mg/mL
Monoclonal
Liquid
RUO
P29533
IgG2a κ
Affinity chromatography
Antibody
429
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization
Unconjugated
Rat
Mouse
22329
Primary
4° C
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SDS
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Product Certifications

For Research Use Only.