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CD11b Rat anti-Mouse, PE-CF594, Clone: M1/70, BD
Rat Monoclonal Antibody
€ 146.59 - € 456.41
Specifications
| Antigen | CD11b |
|---|---|
| Clone | M1/70 |
| Concentration | 0.2mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15891809
|
BD Biosciences
562317 |
25 μg |
 € 148.00 € 146.59 / Each Save € 1.41 0.95% Off |
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|
15891779
|
BD Biosciences
562287 |
0.1 mg |
€ 457.00 € 456.41 / Each Save € 0.59 0.13% Off |
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Description
The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
Specifications
| CD11b | |
| 0.2mg/mL | |
| Monoclonal | |
| Rat | |
| Mouse | |
| Mouse Splenic Cells | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| M1/70 | |
| Flow Cytometry | |
| PE-CF594 | |
| RUO | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| IgG2b κ | |
| Affinity Purified | |
| Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain |
For Research Use Only.
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