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CD178 (Fas Ligand) Mouse anti-Human, Functional Grade, Clone: NOK-1, eBioscience™

Mouse Monoclonal Antibody

Merk:  Affymetrix eBioscience 16-9919-81

Overige gegevens : Gewicht : 0.01000kg

 Bekijk meerdere types van dit product via de

Produktcode. 15248837

  • € 98.25 / 50 µg


Geschatte verzenddatum
bij leverancier 17-01-2020
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Beschrijving

Beschrijving

Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. Fas ligand (FasL, CD95L) is a type-II-membrane protein, whose N-terminus is in the cytoplasm and its C-terminal region extends into the extracellular space. Its receptor Fas (CD95, Apo-1) is a cell-surface-type-I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. As a member of the TNF-cytokine family FasL induces apoptosis when interacting with its receptor Fas. FasL may exist as either membrane bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases. Binding of FasL to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins. FasL is predomitly expressed in activated T-lymphocytes and natural killer (NK) cells also it is expressed in the tissues of immune-privilege sites such as testis and eye. FasL expression is also reported in various tissues as thymus, liver, ovary, lung, heart and kidney. The Fas/FasL system has been shown to play a role in a number of human diseases, for example AIDS, hepatitis or cancer. It is assumed that induction of apoptosis through FasL is predomitly involved in anti-viral immune responses.
Specificatie

Specificatie

CD178 (Fas Ligand)
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
P48023
FasL, apoptosis antigen ligand 1, CD95 ligand, CD95L, CD178, APO1, Fas Ligand, Fas-LG
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Neutralization
NOK-1
Functional Grade
FASLG
Liquid
FASLG
IgG1, kappa
50 μg
4° C
Primary
356
Video's
Documentatie

For Research Use Only.