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CD183 (CXCR3) Armenian Hamster anti-Mouse, Functional Grade, Clone: CXCR3-173, eBioscience™

Armenian Hamster Monoclonal Antibody

Merk:  Affymetrix eBioscience 16-1831-81

Overige gegevens : Gewicht : 0.01000kg

 Bekijk meerdere types van dit product via de

Produktcode. 15248587

  • € 153.00 / 50 µg


Geschatte verzenddatum
bij leverancier 23-01-2020
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Beschrijving

Beschrijving

Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificatie

Specificatie

CD183 (CXCR3)
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
O88410
CD183 , CKR-L2 , CMKAR3 , GPR9 , IP10 , IP10-R , Mig-R , an
Armenian Hamster
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Functional Assay
CXCR3-173
Functional Grade
Cxcr3
Liquid
Cxcr3
IgG
50 μg
4° C
Primary
12766
Video's
Documentatie

For Research Use Only.