CD184 (CXCR4) Mouse anti-Human, Clone: 12G5, eBioscience™
Mouse Monoclonal Antibody
Merk: Affymetrix eBioscience 14-9999-80
Overige gegevens : Gewicht : 0.01000kg
BeschrijvingAggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
|PBS with 0.09% sodium azide; pH 7.2|
|CXC Chemokine Receptor 4, Fusin, LESTR, HUMSTR|
|Flow Cytometry, Functional Assay, Neutralization|
For Research Use Only.