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CD184 (CXCR4), APC, clone: 2B11, eBioscience™

Rat Monoclonal Antibody

Merk:  Affymetrix eBioscience 17-9991-80

Overige gegevens : Gewicht : 0.25000kg

 Bekijk meerdere types van dit product via de

Produktcode. 15330860

  • € 119.00 / 25 µg


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Beschrijving

Beschrijving

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Specificatie

Specificatie

CD184 (CXCR4)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P70658
CXC Chemokine Receptor 4, Fusin, LESTR, HUMSTR
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
2B11
APC
Cxcr4
Liquid
Cxcr4
IgG2b, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
12767
Video's

For Research Use Only.