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CD196 (CCR6) Monoclonal Antibody (R6H1), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

€ 117.00 - € 222.00

Specifications

Antigen CD196 (CCR6)
Clone R6H1
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15247287
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Affymetrix eBioscience
14-1969-80
25 μg
€ 117.00
25µg
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Estimated Shipment: 08-05-2024
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15257287
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Affymetrix eBioscience
14-1969-82
100 μg
€ 222.00
100µg
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Description

Description

Description: This R6H1 monoclonal antibody reacts with CD196 (also known as CCR6), a seven transmembrane G protein-coupled receptor expressed on T, B, dendritic, natural killer, and Langerhans cells. This CC chemokine receptor uniquely binds MIP-3a/CCL20, a chemoattractant for dendritic cells, effector/memory T cells, and B cells. CD196 is also involved in host defense and inflammation at epithelial sites. Furthermore, this receptor has been implicated in Th17 differentiation and CD4+FoxP3+ regulatory T cell development. Applications Reported: This R6H1 antibody has been reported for use in flow cytometric analysis, immunoblotting (WB), and immunoprecipitation. Applications Tested: This R6H1 antibody has been tested by western blot on lysates prepared from normal human peripheral blood cells. This antibody can be used at less than or equal to 5 μg/mL. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
Specifications

Specifications

CD196 (CCR6)
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
BN-1; CC chemokine receptor 6; C-C chemokine receptor type 6; C-C CKR-6; C-C motif chemokine receptor 6; CC-CKR-6; CCR6; CCR-6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; chemokine receptor-like 3; CKR6; CKRL3; CKR-L3; Cmkbr6; DCR2; DRY6; DRY-6; G protein-coupled receptor 29; GPR29; GPRCY4; GPR-CY4; G-protein coupled receptor 29; KY411; LARC receptor; seven-transmembrane receptor, lymphocyte, 22; STRL22
CCR6
Primary
4° C
CCR6
R6H1
Flow Cytometry, Immunoprecipitation, Western Blot
Unconjugated
Mouse
Human
P51684
1235
IgG1 κ
Affinity chromatography
Antibody
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