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CD21 Mouse anti-Human, APC, Clone: HB5, eBioscience™

Mouse Monoclonal Antibody

Merk:  Affymetrix eBioscience 17-0219-42

Overige gegevens : Gewicht : 0.01000kg

 Bekijk meerdere types van dit product via de

Produktcode. 12692049

  • € 261.00 / 1 stuk


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Beschrijving

Beschrijving

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintece of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.
Specificatie

Specificatie

CD21
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P20023
EBV receptor, complement C3d receptor, complement receptor type 2, epstein-Barr virus receptor
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
HB5
APC
CR2
Liquid
CR2
IgG2a, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
1380
Video's

For Research Use Only.