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  6. Invitrogen™ CD21 Recombinant Rabbit Monoclonal Antibody (257), PE, Invitrogen™

Invitrogen™ CD21 Recombinant Rabbit Monoclonal Antibody (257), PE, Invitrogen™
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Product Code. p-200064546
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25 Tests
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Product Code. Quantity unitSize
30019625 100 Tests Pack of 100
30019979 25 Tests Pack of 25
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Product Code. 30019625 Supplier Invitrogen™ Supplier No. MA552254

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Description

Rabbit Recombinant Monoclonal Antibody

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD21
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone 257
Concentration 100 μg/mL
Conjugate PE
Formulation PBS with 0.05% BSA and 0.09% sodium azide
Gene CR2
Gene Accession No. P20023
Gene Alias C3b/C4b receptor; C3-binding protein; C3BR; C3DR; C4BR; CD21; CD35; CD35 antigen; cell surface receptor for C3d; complement C3b/C4b receptor 1 (Knops blood group); complement C3d receptor; Complement C3d receptor (C3DR); complement C3d receptor 2; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3d/Epstein Barr virus) receptor 2; complement component 3b/4b receptor 1 (Knops blood group); complement component 3d receptor 2; complement component receptor 2; complement receptor 1 long isoform; complement receptor 2; complement receptor type 1; complement receptor type 1-like protein; complement receptor type 2; Complement Receptor type 2 (CR2); CR; CR1; Cr-1; CR1-L; Cr2; Cr-2; CVID7; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; expressed in B lymphocytes; KN; Knops blood group antigen; LOW QUALITY PROTEIN: complement receptor type 1; SLEB9
Gene Symbols CR2
Host Species Rabbit
Immunogen Recombinant Human CD21 Protein (Ile 21-Arg971).
Purification Method Protein A
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1380
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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