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Invitrogen™ CD223 (LAG-3) Monoclonal Antibody (4H6A3)
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Product Code. 17915551
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
17915551 100 μg 100µg
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Product Code. 17915551 Supplier Invitrogen™ Supplier No. MA548534

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Description

Mouse Monoclonal Antibody

CD223 (LAG-3) Monoclonal Antibody for Western Blot, Flow, ELISA

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
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Specifications

Antigen CD223 (LAG-3)
Applications ELISA, Flow Cytometry, Western Blot
Classification Monoclonal
Clone 4H6A3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene LAG3
Gene Accession No. P18627
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols LAG3
Host Species Mouse
Immunogen Purified recombinant fragment of human CD223 (AA: extra 66-199) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3902
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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