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  6. Invitrogen™ CD223 (LAG-3) Recombinant Rabbit Monoclonal Antibody (BLR027F)

Invitrogen™ CD223 (LAG-3) Recombinant Rabbit Monoclonal Antibody (BLR027F)
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Product Code. 17755619
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100 μL
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17755619 100 μL 100µL
17765619 10 μL 10µL
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Product Code. 17755619 Supplier Invitrogen™ Supplier No. MA544249

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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
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Specifications

Antigen CD223 (LAG-3)
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
Classification Recombinant Monoclonal
Clone BLR027F
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene LAG3
Gene Accession No. P18627
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols LAG3
Host Species Rabbit
Immunogen Peptide representing a region between residue 500 to 525 of human lymphocyte activation gene 3 protein (LAG3).
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3902
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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