CD28 Syrian Hamster anti-Mouse, Functional Grade, Clone: 37.51, eBioscience™
Syrian Hamster Monoclonal Antibody
Merk: Affymetrix eBioscience 16-0281-86
Overige gegevens : Gewicht : 0.01000kg
BeschrijvingCD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
|PBS with no preservative; pH 7.2|
|MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28|
|Flow Cytometry, Functional Assay|
For Research Use Only.