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  6. CD33 Rabbit anti-Human, Polyclonal, Proteintech

CD33 Rabbit anti-Human, Polyclonal, Proteintech

Product Code. p-7207443 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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Product Code. Quantity unitSize
16807324 20 μL 20µL
16897314 150 μL 150µL
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Product Code. 16807324 Supplier Proteintech Supplier No. 174251AP20UL

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Description

Rabbit Polyclonal Antibody

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

Specifications

Antigen CD33
Applications Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CD33
Gene Accession No. P20138
Gene Alias CD33, CD33 molecule, gp67, p67, SIGLEC 3, SIGLEC3
Gene Symbols CD33
Host Species Rabbit
Immunogen CD33 Fusion Protein Ag11490
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 945
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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