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  6. Invitrogen™ CD365 (Tim-1) Monoclonal Antibody (RMT1-4), eBioscience™, Invitrogen™

Invitrogen™ CD365 (Tim-1) Monoclonal Antibody (RMT1-4), eBioscience™, Invitrogen™
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Product Code. 15297517
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Product Code. 15297517 Supplier Invitrogen™ Supplier No. 14586182

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Description

Rat Monoclonal Antibody

The RMT1-4 MAb reacts with mouse CD365 (also known as TIM1 and HAVCR1) and is a member of the T cell immunoglobulin domain, mucin-like domain (TIM) gene family. CD365 has been found on activated CD4+ T cells, mast cells, and a subset of B cells. CD365 is involved in renal injury, tissue homeostasis, and T cell costimulation. CD365 promotes the differentiation of Th2 cells and the production of IL-4. CD365 can bind several ligands, including Hepatitis A virus, phosphatidylserine, TIM4, IgA, as well as itself. CD365 and TIM4 can mediate uptake of apoptotic cells through recognition of phosphatidylserine. CD365, as well as the other TIM family members, are associated with susceptibility to atopic and autoimmune diseases. In humans, certain polymorphic variants of CD365 are strongly associated with protection against atopy, and this association occurs only in individuals who have had past infection with hepatitis A virus (HAV).

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
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Specifications

Antigen CD365 (Tim-1)
Applications Flow Cytometry
Classification Monoclonal
Clone RMT1-4
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Havcr1
Gene Accession No. Q5QNS5
Gene Alias AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Gene Symbols Havcr1
Host Species Rat
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171283
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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