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CD45.1, APC-eFluor 780, clone: A20, eBioscience™

Mouse Monoclonal Antibody

Merk:  Affymetrix eBioscience 47-0453-80

Overige gegevens : Gewicht : 0.25000kg

 Bekijk meerdere types van dit product via de

Produktcode. 15331630

  • € 98.00 / 25 µg


Geschatte verzenddatum
bij leverancier 26-02-2019
Toevoegen aan winkelmandje

Beschrijving

Beschrijving

Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 633-647 nm; Emission: 780 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
Specificatie

Specificatie

CD45.1
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P06800
CD45, L-CA, Lca, RT7, T200
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
A20
APC-eFluor® 780
Ptprc
Liquid
Ptprc
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
19264
Video's

For Research Use Only.