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Invitrogen™ CD45RO Monoclonal Antibody (IL-A116)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA528403
This item is not returnable.
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Description
Mouse anti Bovine CD45RO, clone IL-A116 recognizes the bovine homologue of the human CD45RO cell surface antigen.
CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Specifications
| CD45RO | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.09% sodium azide | |
| 0 | |
| PTPRC | |
| Bovine peripheral blood mononuclear cells. | |
| 100 μg | |
| Primary | |
| Bovine | |
| Antibody | |
| IgG3 |
| Flow Cytometry, Immunoprecipitation | |
| IL-A116 | |
| Unconjugated | |
| PTPRC | |
| B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen | |
| Mouse | |
| Protein A | |
| RUO | |
| 407152 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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