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CD45RO Mouse, anti-Human, Alexa Fluor 488, Clone: UCHL1, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60097AD

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Product Code. 17158981

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Description

Description

  • The UCHL1 antibody reacts with an extracellular epitope on CD45RO, which is the shortest isoform of CD45, a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily)
  • Alternative splicing of exons 4, 5 and 6 that encode the extracellular RA, RB and RC polypeptides of CD45 gives rise to up to 8 isoforms with molecular masses of 180 - 240 kDa
  • Excision of all three exons generates the ∼180 kDa CD45RO isoform, which is expressed on activated and memory (but not naive) T cells, some B cell subsets, activated monocytes and macrophages, and granulocytes
  • CD45RO enhances both T cell receptor- and B cell receptor-mediated activation and is a known ligand for CD22 on B cells
  • The UCHL1 antibody has been used to identify T cell lymphomas and leukemia and is commonly used in combination with antibodies against CD45RA to discern memory and naive T cells
  • The UCHL1 epitope is destroyed by treatment with neuraminidase or O-glycosidase
Specifications

Specifications

CD45RO
Monoclonal
Alexa Fluor 488
100 Tests
Marmoset, Chimpanzee, Human
Leukocytes, T Cells, T Cells, CD4+, T Cells, CD8+
Immunohistochemistry, Western Blot, ELISA, Flow Cytometry, Immunocytochemistry
UCHL1
Mouse
Primary
IgG2a κ
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