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CD46 Antibody (122.2), Allophycocyanin/Cy7, Novus Biologicals™
Mouse Monoclonal Antibody
Brand: Novus Biologicals NBP2-33159APCCY7
This item is not returnable.
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Description
CD46 Monoclonal specifically detects CD46 in Human samples. It is validated for Flow Cytometry.
Specifications
| CD46 | |
| Monoclonal | |
| APC-Cyanine7 | |
| PBS with 0.05% Sodium Azide | |
| CD46 | |
| Recombinant human CD46 protein (Uniprot: P15529) | |
| 0.1 mL | |
| Primary | |
| CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. | |
| Store at 4°C in the dark. Do not freeze. |
| Flow Cytometry | |
| 122.2 | |
| Flow Cytometry | |
| AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen | |
| Mouse | |
| Protein A or G purified | |
| Cancer, Cell Biology, Cellular Markers, Immunology | |
| 4179.0 | |
| Human | |
| IgG1 κ |
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