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CD47, APC, clone: miap301, eBioscience™

Rat Monoclonal Antibody

Merk:  Affymetrix eBioscience 17-0471-82

Overige gegevens : Gewicht : 0.25000kg

 Bekijk meerdere types van dit product via de

Produktcode. 15330630

  • € 234.00 / 100 µg


Geschatte verzenddatum
bij leverancier 29-03-2019
Toevoegen aan winkelmandje

Beschrijving

Beschrijving

2 μm post- manufacturing filtered. CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Functionally, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. CD47 is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 has broad tissue distribution, is reduced in expression on Rh erythrocytes. CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion, T cell activation, and is involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
Specificatie

Specificatie

CD47
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q61735
IAP, MER6, OA3, CD47 antigen, CD47 glycoprotein, Rh-related antigen, leukocyte surface antigen CD47
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
miap301
APC
Cd47
Liquid
Cd47
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16423
Video's

For Research Use Only.