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CD51 (Integrin αV) Mouse, anti-Human, Biotin, Clone: NKI-M9, STEMCELL Technologies

Product Code. 17168741
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Quantity:
100 μg
Unit Size:
100µg
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17168741 100 μg 100µg
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Product Code. 17168741 Supplier Stemcell Technologies Supplier No. 60043BT

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Description

Mouse Monoclonal Antibody

  • The NKI-M9 antibody reacts with CD51 (vitronectin receptor α chain, or integrin αV), a type I transmembrane glycoprotein containing two subunits (125 kDa and 24 kDa) which are generated by post-translational cleavage and are linked by a disulfide bond
  • CD51 associates non-covalently with integrin β1 (CD29), β3 (CD61), β5, β6, or β8 to form heterodimeric cell adhesion receptors for extracellular matrix components such as fibrinogen, collagen, fibronectin, laminin, osteopontin, thrombospondin, vitronectin, and von Willebrand factor
  • For example, association of CD51 and CD61 forms the integrin αv/β3 receptor primarily involved in binding vitronectin
  • CD51 is expressed broadly on many types of cells, including endothelial cells, fibroblasts, monocytes, macrophages, platelets (at relatively low levels), and osteoclasts
  • It is also found on hepatoma, melanoma, and neuroblastoma cells

Specifications

Antigen CD51 (Integrin αV)
Applications Immunoprecipitation, ELISA, Flow Cytometry, Functional Assay
Classification Monoclonal
Clone NKI-M9
Conjugate Biotin
Host Species Mouse
Quantity 100 μg
Primary or Secondary Primary
Target Species Human
Isotype IgG2a κ
Cell Type Mesenchymal Stem and Progenitor Cells
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