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Invitrogen™ CD6 Monoclonal Antibody (MEM-98)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA119078
This item is not returnable.
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Description
This antibody reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells. Western Blot: non-reducing conditions.
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
Specifications
| CD6 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 15mM sodium azide; pH 7.4 | |
| P30203 | |
| CD6 | |
| Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) (aa 125-128). | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| MEM-98 | |
| Unconjugated | |
| CD6 | |
| Cd6; CD6 antigen; CD6 antigen, Tp120; Cd6 molecule; FLJ44171; OX52; Soluble CD6; T12; T-cell differentiation antigen CD6; TP120 | |
| Mouse | |
| Protein A | |
| RUO | |
| 923 | |
| 4°C, do not freeze | |
| Liquid |
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