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Invitrogen™ CD7 Monoclonal Antibody (LT7)
Mouse Monoclonal Antibody
€ 652.00
Specifications
| Antigen | CD7 |
|---|---|
| Clone | LT7 |
| Concentration | 1 mg/mL |
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Applications | Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation |
Description
CD7 Monoclonal Antibody for IHC (F), Flow, IP
CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.Specifications
| CD7 | |
| 1 mg/mL | |
| Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation | |
| Unconjugated | |
| Mouse | |
| RUO | |
| PBS with 0.09% sodium azide | |
| P09564 | |
| 924 | |
| Normal human peripheral blood lymphocytes. | |
| Antibody |
| LT7 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Monoclonal | |
| Liquid | |
| IgG2a | |
| Human | |
| CD7 | |
| Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41 | |
| CD7 | |
| Primary | |
| Protein A |
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