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CD86 (B7-2) Rat anti-Mouse, Biotin, Clone: GL1, eBioscience™
Rat Monoclonal Antibody
Merk: Affymetrix eBioscience 13-0862-82
Overige gegevens : Gewicht : 0.25000kg
Beschrijving
Filtration: 0.2 μm post-manufacturing filtered. CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.Specificatie
CD86 (B7-2) | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
P42082 | |
B7-2, B7.2, B70, CD28LG2, LAB72, MGC34413, B-lymphocyte activation antigen B7-2, B-lymphocyte antigen B7-2, B7-2 antigen, BU63, CD28 antigen ligand 2 | |
Rat | |
Affinity chromatography | |
RUO | |
Antibody | |
Monoclonal | |
Mouse |
Flow Cytometry | |
GL1 | |
Biotin | |
Cd86 | |
Liquid | |
Cd86 | |
IgG2a, kappa | |
100 μg | |
4° C, store in dark, DO NOT FREEZE! | |
Primary | |
12524 |
For Research Use Only.