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  6. CD95 Hamster anti-Mouse, PE, Clone: JO2, BD

CD95 Hamster anti-Mouse, PE, Clone: JO2, BD

Product Code. 15877628
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Quantity:
0.2 mg
25 μg
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Each
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Product Code. Quantity unitSize
15877628 0.2 mg Each
15891529 25 μg Each
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Product Code. 15877628 Supplier BD Biosciences Supplier No. 554258

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Description

Hamster Monoclonal Antibody

Fas antigen, CD95, is a 45kDa cell-surface protein which can mediate apoptosis. It belongs to the TNF (tumor necrosis factor)/NGF receptor family. Expression of Fas has been described in the thymus, liver, heart, lung and ovary. Fas plays an important role in the apoptotic process that takes place during development. Monoclonal antibodies recognizing Fas such as Jo2 have cytolytic activity on cells expressing Fas. The cell death stimulated by Fas antibodies is characteristic of apoptosis and suggests that the lethal effects are a result of interaction of antibody with a functional Fas antigen as opposed to complement-mediated lysis.
The Jo2 antibody recognizes mouse Fas. The Jo2 antibody shows cytolytic activity against cell lines expressing mouse Fas by inducing apoptosis. Intraperitoneal injections of Jo2 mAb have been shown to kill mice and induce apoptotic hepatocyte death. Jo2 mAb immunoprecipitates mouse Fas as a 45kDa band from W4 cells. W4 cells are WR19L mouse lymphoma cells transformed with mouse Fas. The difference between the observed MW of Fas and that deduced from its amino acid sequence (Mr 34,971) may be due to glycosylation.

Host Species: Hamster
Clone: Jo2
Isotype: IgG2 λ2
Species Reactivity: Mouse
Immunogen: WR19L mouse lymphoma cells transformed with recombinant mouse Fas

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD95
Applications Flow Cytometry
Classification Monoclonal
Clone JO2
Concentration 0.2mg/mL
Conjugate PE
Description Apo-1; Apt1; Fas; FASLG receptor; lpr; TNFR6; Tnfrsf6; TNR6
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Hamster
Immunogen WR19L mouse lymphoma cells transformed with recombinant mouse Fas
Purification Method Affinity Purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2
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For Research Use Only.

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