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Invitrogen™ Cdc20 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA534775
This item is not returnable.
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Description
Recommended positive controls: HeLa, THP-1. Predicted reactivity: Mouse (94%), Rat (94%), Pig (97%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Specifications
| Cdc20 | |
| Polyclonal | |
| Unconjugated | |
| CDC20 | |
| 2310042N09Rik; bA276H19.3; C87100; cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55cdc; XELAEV_18025163mg; X-FZY | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 991 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunoprecipitation, Western Blot | |
| 1 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| Q12834 | |
| CDC20 | |
| Recombinant protein encompassing a sequence within the center region of human CDC20. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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