Cdc25C Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Description

Keep as concentrated solution. Positive Control: Jurkat, Raji, K562, NCI-H929, HeLa (untreated), HeLa (100ng/ml Nocodazole treatment for 24hr), Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

M-phase inducer phosphatase 3is an enzyme that in humans is encoded by theCDC25Cgene. This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. Also, it is thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.