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Invitrogen™ CDK8 Polyclonal Antibody
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Product Code. 15981755
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Quantity:
100 μL
Unit Size:
100µL
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15981755 100 μL 100µL
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Product Code. 15981755 Supplier Invitrogen™ Supplier No. PA575231

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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK8
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.2
Gene Cdk8
Gene Accession No. P49336, Q8R3L8
Gene Alias Cdk8; CDK8 protein kinase; cell division protein kinase 8; Cell division protein kinase 8-like protein; cyclin dependent kinase 8; cyclin-dependent kinase 8; K35; mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; protein kinase K35; RGD1560888; wu:fk95h11
Gene Symbols Cdk8
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids N-terminus of Human CDK8.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1024, 264064, 498140
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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