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CDKN2A Monoclonal Antibody (OTI11D3), TrueMAB™, OriGene

Product Code. 17542504
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100 μL
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17542504 100 μL 100µL
17562504 30 μL 30µL
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Product Code. 17542504 Supplier Origene Technologies Supplier No. TA809881

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Description

Mouse Monoclonal Antibody

In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.

Specifications

Antigen CDKN2A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI11D3
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CDKN2A
Gene Accession No. Q8N726
Gene Alias ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
Gene Symbols CDKN2A
Host Species Mouse
Immunogen Full length human recombit protein of human CDKN2A produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1029
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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