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CENPO Monoclonal Antibody (OTI7F9), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA809481
This item is not returnable.
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Description
Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.Specifications
| CENPO | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9BU64 | |
| CENPO | |
| Human recombit protein fragment corresponding to amino acids 1-230 of human CENPO produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Western Blot | |
| OTI7F9 | |
| Unconjugated | |
| CENPO | |
| CENP-O, ICEN-36, MCM21R | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 79172 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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