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DiscoverX ChemiBrite™ DP Prostanoid Receptor Stable Cell Line

Product Code. 17395159
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17395159

Brand: DiscoverX HTS091L

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This item is not returnable. View return policy

Description

The ChemiBrite™ DP Prostanoid Receptor Stable Cell Line measures PTGDR (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiBrite DP Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of PTGDR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGDR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGDR , the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line 293H
For Use With (Application) Cell Lines
Primary Agonist Prostaglandin D2
Quantity 2 Vials
Target Entry PTGDR
Accession Number AY507142
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